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Hemoglobin Variants by Surface Antibody Screening (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test detects specific types of hemoglobin variants in your blood, which may be linked to inherited blood disorders or conditions affecting red blood cells.

Quick summary

["Identifies unusual hemoglobin forms that could indicate genetic blood conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58405-2
Short code
HBV surface Ab s/co Ser
Synonyms
HBV surface Ab s/co Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like anemia, unusual fatigue, or a family history of hemoglobin disorders. It’s also used when diagnosing conditions such as sickle cell disease or thalassemia.

How the Test Works

Blood is drawn and processed to separate serum, where antibodies are used to detect and classify different hemoglobin variants. This helps determine if your blood contains unusual hemoglobin forms beyond standard types.

What to Expect Before the Test

No special preparation is needed. You may have a slight bruise or discomfort at the needle site, but most people find it quick and manageable. Avoid heavy exercise or eating a large meal before testing to ensure accuracy.

What to Expect After the Test

You can resume normal activities immediately. If you experience excessive bleeding or unusual pain, contact your provider. Most results are available within a few days, depending on lab processing times.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant Screening (Serum)

Frequently asked questions

How long does it take to get results from this test?
Results typically take 3 to 7 business days, depending on lab workload and processing. Your healthcare provider will contact you once they are ready to discuss findings.
Can I eat or drink before this test?
No special diet is required, but avoid heavy meals or vigorous activity right before testing to ensure accurate results. Water is fine to drink.
What symptoms might indicate a hemoglobin variant?
Symptoms could include fatigue, pale or yellowish skin, frequent infections, or unusual pain in joints or abdomen. If you experience these, discuss them with your provider, as they may relate to hemoglobin disorders.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy