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Hemoglobin Variants by Surface Antibody Binding (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test helps identify specific types of hemoglobin variants in your blood, which may be linked to conditions like sickle cell disease or other inherited blood disorders.

Quick summary

["This test helps detect unusual hemoglobin forms that could affect blood health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16935-9
Short code
HBV surface Ab Ser-aCnc
Synonyms
HBV surface Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like fatigue, pain, or a family history of hemoglobin disorders. It’s also used to confirm a diagnosis of conditions like sickle cell disease or thalassemia.

What Does the Test Measure?

The test measures the presence of specific hemoglobin variants by detecting how antibodies bind to their surfaces. This helps differentiate between normal and abnormal hemoglobin forms.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is processed to separate serum or plasma for testing. No special preparation is needed, but fasting may be advised depending on other tests ordered with it.

What to Expect During the Test

The test involves a simple blood draw, followed by analysis using advanced laboratory techniques to identify hemoglobin variants. Results are typically available within a few days.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant Screening (Serum/Plasma)

Frequently asked questions

How long does it take to get results from this test?
Results are usually available within 2 to 5 business days, depending on lab processing times and whether additional testing is needed.
What are the common causes for ordering this test?
This test is often ordered if you have symptoms like persistent fatigue, unusual pain, or if you have a family history of blood disorders. It may also be part of a routine screening for certain genetic conditions.
Can I eat or drink before this test?
No specific dietary restrictions apply to this test, but always follow any instructions your healthcare provider gives you regarding fasting or other preparations for related tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy