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Hemoglobin Variants by Surface Antibody Screening (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for different types of hemoglobin in your blood, which may indicate inherited blood disorders like sickle cell disease or other hemoglobinopathies.

Quick summary

["Helps identify rare blood conditions that affect how oxygen travels in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
75409-3
Short code
HBV surface Ab SerPlBld Ql IA.rapid
Synonyms
HBV surface Ab SerPlBld Ql IA.rapid
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia-rapid
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, pain, or unusual blood test results. It’s also used in newborn screening or before certain medical procedures to check for inherited blood disorders.

What to Expect Before the Test

You’ll likely have a simple blood draw from a vein in your arm. No special preparation is needed, but tell your doctor about any medications or recent illnesses.

What the Results Mean

Abnormal results may show unusual hemoglobin types, which can guide treatment or further testing. Your doctor will discuss findings with you based on your symptoms and medical history.

Common Conditions This Test Helps Diagnose

Conditions like sickle cell disease, thalassemia, or other hemoglobinopathies may be detected early with this test, allowing for better management and support.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing inherited blood disorders that can cause anemia, pain crises, or other complications. Early detection improves treatment options and quality of life.

Short name

Hemoglobin Variant Screening (Serum/Plasma)

Frequently asked questions

Will I need to prepare for this test?
No special preparation is needed, but avoid eating or drinking anything for 2–3 hours before the blood draw if instructed by your doctor.
How long will it take to get my results?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will contact you with findings.
Can I fast before this test?
Fasting is not required for this test, but check with your doctor if you have questions about timing or medications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy