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Hemoglobin Variants in Serum (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for abnormal types of hemoglobin, the protein in red blood cells that carries oxygen. Certain variants can affect blood health and may require further evaluation.

Quick summary

["This screening helps identify unusual hemoglobin forms that might indicate genetic conditions or blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49495-5
Short code
HBV surface Ab S SerPl
Synonyms
HBV surface Ab S SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, pale skin, or unusual blood test results. It’s also used in genetic testing for conditions like sickle cell disease or thalassemia.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. The test looks for specific hemoglobin types using a specialized lab method.

What the Results Mean

Positive results show the presence of abnormal hemoglobin variants. These may need further testing to determine the exact type and cause, such as genetic testing or additional blood studies.

Common Conditions Linked to This Test

Variants detected could relate to inherited blood disorders (e.g., sickle cell trait or disease), certain anemia types, or other genetic conditions affecting red blood cells.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant Screening (Serum)

Frequently asked questions

What does a positive result mean for my health?
A positive result indicates the presence of abnormal hemoglobin variants. Your doctor will discuss next steps, which may include additional testing or monitoring to understand the cause and impact on your health.
Can I prevent abnormal hemoglobin variants?
Some variants are genetic and cannot be prevented. However, managing chronic conditions (like diabetes or anemia) and avoiding smoking can help support overall blood health.
How often will I need this test?
Frequency depends on your symptoms, diagnosis, or doctor’s recommendations. Some people may need follow-up tests periodically, while others may only need it once.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy