Hemoglobin Variants by High-Performance Liquid Chromatography (HPLC)
This test measures different types of hemoglobin in your blood, helping identify unusual or abnormal hemoglobin variants that may indicate conditions like sickle cell disease or other blood disorders.
["This test helps diagnose or monitor hemoglobin-related blood conditions."]
Key facts at a glance
- LOINC
- 111512-0
- Short code
- HBV surface Ag DNA mut SerPl Ql Seq
- Synonyms
- HBV surface Ag DNA mut SerPl Ql Seq
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 5
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- sequencing
- CPT
- 82378
- SNOMED
- 394995008
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test if you have symptoms like fatigue, pain, or frequent infections, or if you have a family history of hemoglobin disorders. It may also be used to confirm a diagnosis of conditions like sickle cell disease or thalassemia.
What to Expect Before the Test
No special preparation is needed. A blood sample is drawn from a vein in your arm, similar to a routine blood test. You may feel a slight pinch, but it usually doesn’t cause discomfort.
What the Test Results Mean
The test separates hemoglobin into different variants based on their structure. Abnormal variants may appear as distinct peaks on the test report. Your healthcare provider will interpret the results in the context of your symptoms and medical history.
Common Conditions Linked to This Test
Abnormal hemoglobin variants can be linked to inherited blood disorders such as sickle cell disease, hereditary spherocytosis, or other hemoglobinopathies. These conditions can affect how your red blood cells function and may lead to symptoms like anemia or chronic pain.
Reference range
Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A
No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Hb Variant Profile
Frequently asked questions
What does a positive or abnormal result mean?
How often should I get this test?
Can I prepare for this test at home?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy