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Hemoglobin Variants by Surface Antibody Binding Mass Measurement (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures different forms of hemoglobin in your blood, which can help identify conditions like sickle cell disease or other inherited blood disorders.

Quick summary

["This test helps detect unusual hemoglobin types that may affect your health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109335-0
Short code
HBV surface Ag Msmt Ser
Synonyms
HBV surface Ag Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like fatigue, pain, frequent infections, or if they suspect an inherited blood disorder. It’s also used in prenatal screening or when diagnosing conditions like thalassemia or sickle cell trait.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The test uses a sample of your serum (liquid part of blood after clotting).

How the Test Works

The test analyzes hemoglobin variants by measuring how different antibodies bind to their surfaces. Advanced technology separates and identifies these variants for comparison.

What the Results Mean

Results show the proportion of different hemoglobin types. Abnormal patterns may indicate genetic conditions requiring further testing or treatment. Your provider will discuss findings with you.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant Screening (Serum)

Frequently asked questions

What causes abnormal hemoglobin variants?
Abnormal hemoglobin variants often result from genetic mutations passed down through families. Conditions like sickle cell disease, thalassemia, or other hemoglobinopathies can cause these changes.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will contact you once results are ready.
Can I eat or drink before this test?
No special diet is needed. However, avoid caffeine or heavy meals 2 hours before your blood draw to ensure accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy