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Hemoglobin Variants by Serum Surface Antigen Probe (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test checks for different types of hemoglobin in your blood, which can help identify conditions like sickle cell disease or other blood disorders.

Quick summary

["This simple blood test helps detect unusual hemoglobin forms that may affect your health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
95149-1
Short code
HBV surface Ag Pnl SerPl
Synonyms
HBV surface Ag Pnl SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, pain, or frequent infections, or if you have a family history of blood disorders. It’s also used in newborn screening or before certain medical procedures.

What to Expect Before the Test

You’ll have a small needle inserted into your arm to draw blood. It usually takes a few minutes. No special preparation is needed, but tell your doctor about any medications or conditions that might affect results.

What the Test Results Mean

Positive results may show unusual hemoglobin types, which could indicate genetic blood disorders. Negative results mean no obvious variants were detected in this sample. Follow-up testing may be needed if results are unclear.

Common Conditions Linked to This Test

This test helps diagnose or monitor conditions like sickle cell anemia, thalassemia, or other hemoglobinopathies. It’s also part of newborn screening programs in some places.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant Screening (Qualitative)

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains hemoglobin variants that may suggest a blood disorder like sickle cell disease or thalassemia. Your doctor will discuss next steps, which may include further testing or genetic counseling.
How often should I get this test?
The frequency depends on your health status and symptoms. Your doctor may recommend regular testing if you have a family history of hemoglobin disorders or if you’re at higher risk. Follow their guidance.
Can I eat or drink before this test?
No special diet or fasting is required for this blood test. However, always inform your doctor about any medications or supplements you’re taking, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy