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Hemoglobin Variants by Surface Antigen Detection (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test identifies different types of hemoglobin in your blood, which may help diagnose conditions like sickle cell disease or other inherited blood disorders.

Quick summary

["Checking for unusual hemoglobin forms can help spot genetic blood disorders early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58452-4
Short code
HBV surface Ag Ser-aCnc
Synonyms
HBV surface Ag Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like fatigue, pain, frequent infections, or a family history of blood disorders. It’s also used in newborn screening or before certain surgeries to check for inherited hemoglobin conditions.

What to Expect Before the Test

You’ll typically have a small needle inserted into your arm to draw blood. No special preparation is needed, but tell your doctor about any medications or recent illnesses.

What the Test Results Mean

Results show the proportion of different hemoglobin types. Abnormal patterns may indicate conditions like sickle cell trait or thalassemia. Your doctor will interpret results in the context of your symptoms and medical history.

Common Conditions Linked to This Test

This test helps diagnose inherited blood disorders, such as sickle cell disease, thalassemia, or other hemoglobinopathies. It may also be used for genetic counseling or preconception screening.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is primarily used to detect variations in hemoglobin structure that can cause health problems. Early identification allows for better management and treatment planning, especially in conditions requiring specialized care.

Short name

Hemoglobin Variant Screening (Serum)

Frequently asked questions

What does a positive or abnormal result mean?
An abnormal result may indicate an inherited blood disorder, such as sickle cell trait or thalassemia. Your doctor will discuss next steps, which could include further testing or genetic counseling.
How long will I need to wait for results?
Results are usually available within 1–3 business days, depending on lab processing times. Your doctor will contact you with the findings.
Can I eat or drink before this test?
No special diet is required, but avoid caffeine or alcohol before the blood draw if your doctor recommends it.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy