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Hemoglobin Variants by Surface Antigen Detection (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test checks for different types of hemoglobin in your blood, which may help identify conditions like sickle cell disease or other inherited blood disorders.

Quick summary

["This test helps diagnose or monitor blood disorders linked to abnormal hemoglobin."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
47364-5
Short code
HBV surface Ag Ser Donr Ql IA
Synonyms
HBV surface Ag Ser Donr Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, pain, or frequent infections, or if you have a family history of blood disorders. It can also be part of routine screening for certain genetic conditions.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw a blood sample. The process usually takes a few minutes.

What the Test Results Mean

The test looks for specific surface antigens on hemoglobin molecules. Different patterns may indicate specific hemoglobin variants. Your results will be reviewed by a healthcare professional to determine if further testing or treatment is needed.

Common Conditions Monitored

This test is often used to diagnose or monitor sickle cell disease, thalassemia, and other inherited hemoglobin disorders. It helps track how well treatments are working or if symptoms are worsening.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant Screening

Frequently asked questions

What does a positive or abnormal result mean?
An abnormal result may mean you have a hemoglobin variant linked to a blood disorder. Your doctor will discuss next steps, which could include additional tests or genetic counseling.
How often should I get this test?
Your doctor will determine how often you need this test based on your symptoms, medical history, and treatment plan. Regular monitoring may be recommended if you have a known blood disorder.
Can diet or lifestyle changes affect this test?
While diet and lifestyle factors may influence overall blood health, they typically do not directly affect hemoglobin variant detection. Follow your doctor’s advice for managing any related conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy