Hemoglobin Variants by Surface Antigen Detection in Whole Blood (Rapid Qualitative Screening)
This test checks for abnormal hemoglobin types in your blood that may cause conditions like sickle cell disease or other inherited blood disorders. It uses a rapid qualitative method to detect surface antigens on red blood cells.
["Quick screening for rare hemoglobin variants that could affect blood health."]
Key facts at a glance
- LOINC
- 75410-1
- Short code
- HBV surface Ag SerPlBld Ql IA.rapid
- Synonyms
- HBV surface Ag SerPlBld Ql IA.rapid
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 5
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia-rapid
- CPT
- 82378
- SNOMED
- 394995008
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects specific surface antigens on red blood cells that are associated with certain hemoglobin variants. These variants can sometimes lead to conditions like sickle cell trait or disease, where red blood cells may take on unusual shapes or function poorly.
How the Test Works
This is a rapid qualitative test, meaning it provides a yes/no result rather than a precise measurement. Blood samples are analyzed for the presence of particular antigens on red blood cell surfaces, often using a simple, fast method to identify potential variants.
Why It Might Be Ordered
Your healthcare provider may order this test if you have a family history of hemoglobin disorders, symptoms like fatigue, pain, or frequent infections, or if you are planning pregnancy and there is a risk of genetic conditions.
What to Expect Before the Test
No special preparation is needed. You may have a small needle inserted into your arm to draw a small amount of blood. This process is quick and usually painless.
Reference range
Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A
No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Detecting hemoglobin variants early can help manage conditions like sickle cell disease, where abnormal hemoglobin can cause severe complications. Identifying variants can guide treatment decisions, such as avoiding high-altitude travel or certain medications that may worsen symptoms.
Short name
Hemoglobin Variant Screen (Rapid Qualitative)
Frequently asked questions
What does a positive result mean?
What does a negative result mean?
Can this test be used to diagnose sickle cell disease?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy