Hemoglobin Variants by Surface Antigen Detection (Serum/Plasma)
This test checks for different types of hemoglobin in your blood, which may indicate inherited blood disorders like sickle cell disease or other hemoglobinopathies.
["Helps identify rare blood conditions that affect how your red blood cells function."]
Key facts at a glance
- LOINC
- 70154-0
- Short code
- HBV surface Ag SerPl Cfm-%
- Synonyms
- HBV surface Ag SerPl Cfm-%
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 5
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- confirm
- CPT
- 82378
- SNOMED
- 394995008
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test detects specific surface antigens on hemoglobin molecules. These antigens can vary depending on genetic differences, which may affect how hemoglobin behaves in your blood. This method helps distinguish between normal and abnormal hemoglobin forms.
Why It’s Done
Your healthcare provider may order this test if you have symptoms like fatigue, pain, or a family history of hemoglobin disorders. It’s also used in prenatal screening or before certain medical procedures to assess blood health.
Sample Collection and Preparation
Blood is drawn from a vein, typically in your arm. The sample is processed into serum or plasma for testing. This test does not require fasting but should be done under sterile conditions to ensure accuracy.
What to Expect Before the Test
No special preparation is needed, but inform your doctor about any medications or supplements you take, as they may affect blood results. Avoid strenuous activity 24 hours before the test to prevent false elevations in certain markers.
Reference range
Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A
No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Detecting hemoglobin variants early can prevent complications like anemia, organ damage, or severe pain crises. Identifying the specific variant helps healthcare providers tailor treatments, such as blood transfusions, medications, or lifestyle adjustments.
Short name
Hemoglobin Variant Screening
Frequently asked questions
How long does it take to get results?
What does a positive result mean?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy