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Hemoglobin Variants by Serum Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures different types of hemoglobin in your blood, which can help identify conditions like sickle cell disease or other inherited blood disorders.

Quick summary

["Helps diagnose blood disorders by detecting unusual hemoglobin variants."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
65633-0
Short code
HBV surface Ag SerPl Ql Cfm
Synonyms
HBV surface Ag SerPl Ql Cfm
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
confirm
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Hemoglobin?

Hemoglobin is the protein in red blood cells that carries oxygen from your lungs to the rest of your body. Normally, it contains a specific mix of hemoglobin types, but certain genetic conditions can cause unusual hemoglobin variants.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like fatigue, pain, frequent infections, or if you have a family history of blood disorders. It’s also used in newborn screening or before certain medical procedures.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum for analysis.

What Does the Test Tell You?

The test identifies abnormal hemoglobin forms, which can confirm or rule out conditions like sickle cell trait or disease. Specific patterns may indicate genetic mutations or other blood-related issues.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hemoglobin Variant Screening (Serum Electrophoresis)

Frequently asked questions

What are hemoglobin variants?
Hemoglobin variants are different forms of hemoglobin that may appear in your blood instead of the normal type. These can be caused by genetic mutations and may lead to health problems like anemia or pain crises.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will discuss the findings with you.
Can I eat or drink before this test?
No special diet or fasting is required for this test. However, follow any specific instructions your doctor provides for your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy