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Hemoglobin Variants by Surface Agonist Binding Titer (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the binding capacity of hemoglobin variants to specific surface antigens, helping identify unusual hemoglobin forms that may affect blood health.

Quick summary

["This test helps detect rare hemoglobin variants that could influence blood function or require further medical evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10674-0
Short code
HBV surface Ag Tiss Ql ImStn
Synonyms
HBV surface Ag Tiss Ql ImStn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
5
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
CPT
82378
SNOMED
394995008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like anemia, unusual fatigue, or a family history of hemoglobin disorders. It’s also used in research or specialized diagnostic settings to assess hemoglobin structure.

What to Expect Before the Test

You’ll typically provide a blood sample drawn from your arm. No special preparation is needed, but inform your provider if you’re on blood-thinning medications or have bleeding disorders.

How the Results Are Interpreted

Results compare the binding strength of your hemoglobin to a reference range. Abnormal binding patterns may indicate inherited conditions like sickle cell trait or thalassemia.

Common Conditions Linked to This Test

This test is primarily used to screen for hemoglobinopathies (disorders affecting hemoglobin structure) that may not show up on standard blood tests alone.

Reference range

Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: While this test isn’t routinely part of standard care, it plays a role in diagnosing rare hemoglobin variants that could impact oxygen transport or lead to complications like anemia or blood vessel blockages.

Short name

Hemoglobin Variant Screening (Serum)

Frequently asked questions

What does an abnormal result mean?
An abnormal result suggests your hemoglobin may have structural differences that could affect its function. Your doctor will discuss next steps, which may include genetic testing or further blood evaluations.
Is this test covered by insurance?
Coverage depends on your insurance plan and clinical indication. Check with your provider or insurance company to confirm if this specialized test is approved for your situation.
How long does it take to get results?
Results are typically available within 24–48 hours, depending on lab processing times and whether confirmatory testing is needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy