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Hepatitis B Virus (HBV) Antibody Profile (Qualitative, Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies against the hepatitis B virus in your blood, helping determine if your immune system has ever been exposed to the virus or if you have immunity from vaccination.

Quick summary

["Assesses past or current hepatitis B exposure and vaccination status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43279-9
Short code
HBV YMDD Mut SerPl Ql NAA+probe
Synonyms
HBV YMDD Mut SerPl Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies that your immune system produces in response to hepatitis B virus infection. These antibodies can indicate whether you’ve been exposed to the virus, whether your body cleared the infection, or if you’ve received the hepatitis B vaccine.

Why It’s Done

Your healthcare provider may order this test if you have risk factors for hepatitis B (e.g., travel to regions with high infection rates, sexual history, or exposure to infected blood), if you’re pregnant, or if you’re planning a procedure requiring blood exposure precautions.

What to Expect Before the Test

No special preparation is needed. A blood sample is drawn from a vein, usually in your arm. You may feel a slight pinch, but it’s quick and typically painless.

What the Results Mean

Results are qualitative (positive or negative) and may include different antibody types (e.g., anti-HBs, anti-HBc). Positive results suggest past infection, immunity, or vaccination. Consult your provider for interpretation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HBV Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your body has detected hepatitis B antibodies, which could mean you’ve had the virus before, received the vaccine, or are currently immune. It does not indicate active infection without additional testing.
Can this test detect active hepatitis B?
No, this test alone does not detect active hepatitis B. For active infection, your provider may also check for hepatitis B surface antigen (HBsAg) or viral load.
How often should I get this test?
Your provider will determine the frequency based on your health, risk factors, and medical history. Regular testing may be recommended if you’re at higher risk for hepatitis B.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy