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Haptoglobin in Serum or Plasma (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of haptoglobin, a protein in your blood that helps remove harmful substances and fight infections.

Quick summary

["Haptoglobin helps identify conditions affecting red blood cells or blood breakdown."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22348-7
Short code
H capsul IgA Ser Ql
Synonyms
H capsul IgA Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fatigue, pale skin, or unusual bruising, which could indicate conditions such as hemolysis (destruction of red blood cells), anemia, or certain infections. It may also be used to monitor blood disorders or reactions to medications.

What to Expect Before the Test

No special preparation is usually needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood-thinning medication, let your doctor know before the test.

What the Test Results Mean

Haptoglobin levels can vary based on health conditions, diet, and other factors. Lower levels may suggest red blood cell destruction, while higher levels could be linked to inflammation or other health issues. Your doctor will interpret results in the context of your overall health.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions like hemolytic anemia, liver disease, infections, or reactions to certain drugs. It can also help track how well treatments are working.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Haptoglobin Level

Frequently asked questions

What causes low haptoglobin levels?
Low haptoglobin levels are most commonly linked to conditions that damage red blood cells, such as hemolytic anemia (from infections, autoimmune diseases, or blood disorders). It may also appear in liver disease or severe infections.
What causes high haptoglobin levels?
High haptoglobin levels are less common but may occur in chronic inflammation, certain cancers, or severe burns. Your doctor will consider other factors, like your medical history, to determine the cause.
How often should I get this test?
The frequency depends on your health condition. If you have an ongoing issue like hemolysis or anemia, your doctor may recommend regular monitoring. Otherwise, this test is usually done as needed for specific symptoms or investigations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy