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Haptoglobin in Serum or Plasma (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of haptoglobin, a protein in your blood that helps remove harmful substances and protects red blood cells.

Quick summary

["Haptoglobin helps detect conditions affecting red blood cells or inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16971-4
Short code
H capsul IgA Ser Ql ID
Synonyms
H capsul IgA Ser Ql ID
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-diffusion
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Haptoglobin?

Haptoglobin is a protein produced by the liver that binds to free hemoglobin released when red blood cells break apart. It helps clear toxins from the blood and supports the immune system. Low levels may suggest red blood cell destruction or certain infections.

Why Might You Need This Test?

Your doctor may order this test to investigate symptoms like anemia, jaundice, or unexplained fatigue, or to monitor conditions such as hemolytic anemia, infections, or liver disease.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The blood is processed to separate serum or plasma, and the haptoglobin level is measured using a specialized lab technique.

What Do Results Mean?

Results are compared to a reference range specific to your lab. Low levels may indicate red blood cell breakdown, infections, or other conditions affecting protein production.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Haptoglobin Level

Frequently asked questions

What causes low haptoglobin levels?
Low haptoglobin can result from conditions such as hemolytic anemia (where red blood cells are destroyed), severe infections, liver disease, or certain medications.
What causes high haptoglobin levels?
High haptoglobin levels are less common but may occur in conditions like severe burns, dehydration, or certain types of cancer. Your doctor will discuss results in context with your symptoms and medical history.
How often should I get this test?
Your doctor will determine the frequency based on your health needs, symptoms, or ongoing treatments. Regular follow-ups may be recommended if you have conditions like anemia or liver disease.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy