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Haptoglobin in Serum (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of haptoglobin in your blood serum, a protein that helps remove free hemoglobin (from red blood cell destruction) and binds iron to prevent anemia.

Quick summary

["Haptoglobin helps identify conditions causing red blood cell breakdown."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109319-4
Short code
H capsul IgM Msmt Ser
Synonyms
H capsul IgM Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to check for conditions that cause red blood cells to break down too quickly, such as hemolytic anemia (a type of anemia where red blood cells are destroyed faster than they can be made). It can also help evaluate bleeding disorders or certain infections.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re nervous, let your healthcare provider know so they can help make you more comfortable.

What the Test Results Mean

Haptoglobin levels vary depending on health conditions. Low levels often suggest red blood cell destruction (hemolysis), while normal or high levels may indicate other factors like iron overload or inflammation.

Common Conditions Affecting Results

Low haptoglobin is commonly seen in hemolytic anemia (from infections, autoimmune diseases, or blood disorders). High levels may occur in conditions like iron overload or severe inflammation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Haptoglobin Level

Frequently asked questions

What causes haptoglobin levels to be low?
Low haptoglobin is most commonly linked to hemolytic anemia, where red blood cells are destroyed faster than the body can replace them. This can happen due to infections, autoimmune diseases (like lupus), blood disorders, or certain medications.
Can haptoglobin levels be affected by diet or medications?
Dietary factors rarely affect haptoglobin levels, but some medications (like certain antibiotics or blood thinners) may indirectly influence red blood cell health. Always discuss any medications with your doctor.
How often should this test be repeated?
Your doctor will determine how often to repeat this test based on your symptoms and medical history. If you have a chronic condition like hemolytic anemia, follow-up tests may be scheduled regularly to monitor progress.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy