Bicarbonate (HCO₃⁻) concentration in serum/plasma
This test measures the amount of bicarbonate, a key chemical in your blood that helps regulate your body’s acid-base balance.
["Bicarbonate helps balance acidity in your blood, which is crucial for normal heart, kidney, and nerve function."]
Key facts at a glance
- LOINC
- 94001-5
- Short code
- HCO3 1h p Vaso SerPl-sCnc
- Synonyms
- HCO3 1h p Vaso SerPl-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 22
- Ref high
- 28
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does Bicarbonate Measure?
Bicarbonate is a critical buffer in your blood, helping to maintain a stable pH (acidity level). It works alongside carbon dioxide and oxygen to keep your blood chemistry in balance. Abnormal levels can indicate conditions like metabolic acidosis or alkalosis, which may affect how your body processes nutrients or responds to stress.
Why Is This Test Done?
Your doctor may order this test if you have symptoms like confusion, rapid breathing, fatigue, or muscle cramps. It’s also used to diagnose or monitor conditions such as kidney disease, diabetes, or heart problems. Sometimes, it’s checked alongside other blood tests to assess overall health or response to treatments.
How Is the Test Performed?
A small blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed to measure bicarbonate levels. No special preparation is needed, but you may be asked to fast or avoid certain medications before the test, depending on your doctor’s instructions.
What Are Possible Results?
Results are typically reported as a numerical value (e.g., mmol/L) but aren’t always provided with a specific range. Your doctor will compare your result to your body’s normal balance and consider your symptoms and medical history to interpret it.
Reference range
NCBI: HCO3- 22-28 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Serum bicarbonate level
Frequently asked questions
What Does a Low Bicarbonate Level Mean?
What Does a High Bicarbonate Level Mean?
How Often Should I Get This Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy