Bicarbonate concentration in blood (serum/plasma)
This test measures the amount of bicarbonate, a key chemical in your blood that helps balance acidity and alkalinity. It’s part of your body’s effort to maintain healthy pH levels.
["Bicarbonate helps regulate your body’s acid-base balance and supports normal blood chemistry."]
Key facts at a glance
- LOINC
- 28641-9
- Short code
- HCO3 BldCoV-sCnc
- Synonyms
- HCO3 BldCoV-sCnc
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 22
- Ref high
- 28
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Your bicarbonate level is closely tied to how well your body maintains a stable pH in your blood. Low or high levels can signal conditions like metabolic acidosis or alkalosis, which may affect organs like your heart, kidneys, or lungs. This test is often checked when you have symptoms like fatigue, confusion, or unusual breathing patterns.
What to Expect Before the Test
No special preparation is needed for this test. You’ll have a small needle inserted into your arm or vein to draw blood. If you’re fasting, check with your healthcare provider first, as some tests may require it. Avoid smoking or caffeine before the draw if instructed.
What the Results Mean
Bicarbonate levels can fluctuate based on diet, medications, kidney function, and breathing. Your results will be compared to a reference range provided by your lab. While exact ranges vary by lab, low levels may indicate conditions like kidney disease or severe vomiting, while high levels could suggest overuse of antacids or certain breathing disorders.
Common Conditions Linked to Bicarbonate Levels
Abnormal bicarbonate levels can signal metabolic or respiratory disorders. For example, low bicarbonate might be seen in diabetic ketoacidosis or kidney failure, while high levels could occur with overproduction of bicarbonate from medications or conditions like chronic obstructive pulmonary disease (COPD). Your doctor will discuss these findings in relation to your overall health.
Reference range
NCBI: HCO3- 22-28 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Bicarbonate Level
Frequently asked questions
What causes bicarbonate levels to be tested?
Will fasting affect my bicarbonate test results?
How long does it take to get my bicarbonate test results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy