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Bicarbonate concentration in blood (serum/plasma)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of bicarbonate, a key chemical in your blood that helps balance acidity and alkalinity. It’s part of your body’s effort to maintain healthy pH levels.

Quick summary

["Bicarbonate helps regulate your body’s acid-base balance and supports normal blood chemistry."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
28641-9
Short code
HCO3 BldCoV-sCnc
Synonyms
HCO3 BldCoV-sCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
22
Ref high
28
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Your bicarbonate level is closely tied to how well your body maintains a stable pH in your blood. Low or high levels can signal conditions like metabolic acidosis or alkalosis, which may affect organs like your heart, kidneys, or lungs. This test is often checked when you have symptoms like fatigue, confusion, or unusual breathing patterns.

What to Expect Before the Test

No special preparation is needed for this test. You’ll have a small needle inserted into your arm or vein to draw blood. If you’re fasting, check with your healthcare provider first, as some tests may require it. Avoid smoking or caffeine before the draw if instructed.

What the Results Mean

Bicarbonate levels can fluctuate based on diet, medications, kidney function, and breathing. Your results will be compared to a reference range provided by your lab. While exact ranges vary by lab, low levels may indicate conditions like kidney disease or severe vomiting, while high levels could suggest overuse of antacids or certain breathing disorders.

Common Conditions Linked to Bicarbonate Levels

Abnormal bicarbonate levels can signal metabolic or respiratory disorders. For example, low bicarbonate might be seen in diabetic ketoacidosis or kidney failure, while high levels could occur with overproduction of bicarbonate from medications or conditions like chronic obstructive pulmonary disease (COPD). Your doctor will discuss these findings in relation to your overall health.

Reference range

NCBI: HCO3- 22-28 mmol/LN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Bicarbonate Level

Frequently asked questions

What causes bicarbonate levels to be tested?
Your doctor may order this test if you have symptoms like unusual fatigue, confusion, rapid breathing, or nausea. It’s also used to monitor conditions like kidney disease, diabetes, or heart problems. Sometimes, it’s part of a broader blood chemistry panel to check how well your body is balancing acids and bases.
Will fasting affect my bicarbonate test results?
Fasting may influence bicarbonate levels, as your body’s metabolism changes when you haven’t eaten. If your doctor recommends fasting, follow their instructions carefully. If not, avoid heavy meals or caffeine before the test to ensure accurate results.
How long does it take to get my bicarbonate test results?
Results are typically available within 1–3 business days, depending on your lab and healthcare provider. Your doctor will contact you once they’re ready to discuss the findings with you.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy