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Bicarbonate Ion Concentration in Blood (Serum or Plasma)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of bicarbonate ions in your blood, which helps balance acidity (pH). Bicarbonate is a key part of your body’s acid-base balance system.

Quick summary

["Bicarbonate levels help doctors check if your body is too acidic or alkaline."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
97543-3
Short code
HCO3 BldCV-sCnc
Synonyms
HCO3 BldCV-sCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
22
Ref high
28
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Your body maintains a delicate balance between acids and bases to keep your organs functioning properly. Bicarbonate is one of the main ways your blood helps regulate this balance. Low levels may suggest conditions like metabolic acidosis, while high levels could indicate metabolic alkalosis. This test is often used alongside other blood tests, like blood pH, to diagnose and monitor conditions affecting acid-base balance.

What to Expect Before the Test

No special preparation is usually needed for this test. You may have a small needle inserted into a vein in your arm to draw blood. The process is quick and typically painless. If you’re on blood thinners or have a history of bleeding issues, let your healthcare provider know.

What the Results Mean

Results are usually reported as a concentration value (often in milliequivalents per liter, mEq/L). While reference ranges can vary by lab, very high or very low levels may signal underlying health concerns that need further investigation.

Common Conditions Monitored

Doctors may order this test to diagnose or monitor conditions such as kidney disease, diabetes, heart failure, or gastrointestinal issues that affect acid-base balance. It’s also used in cases of suspected metabolic disorders or after injuries that might disrupt normal blood chemistry.

Reference range

NCBI: HCO3- 22-28 mmol/LN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Bicarbonate Level

Frequently asked questions

What causes bicarbonate levels to be too high or too low?
High bicarbonate levels may be due to conditions like vomiting, excessive vomiting, or certain medications that increase stomach acid loss. Low bicarbonate levels can result from kidney problems, severe diarrhea, or metabolic acidosis caused by diabetes, kidney failure, or certain medications.
Can diet affect bicarbonate levels?
Dietary choices can indirectly influence bicarbonate levels. For example, diets high in salt or certain medications (like diuretics) may affect kidney function, which in turn impacts bicarbonate. However, bicarbonate itself isn’t directly affected by what you eat, but overall acid-base balance can be.
How often should I get this test?
The frequency depends on your health condition. If you have a chronic illness like kidney disease or diabetes, your doctor may recommend regular monitoring. Otherwise, this test is usually ordered as needed for specific symptoms or medical evaluations.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy