Bicarbonate Ion Concentration in Blood (Serum or Plasma)
This test measures the amount of bicarbonate ions in your blood, which helps balance acidity (pH). Bicarbonate is a key part of your body’s acid-base balance system.
["Bicarbonate levels help doctors check if your body is too acidic or alkaline."]
Key facts at a glance
- LOINC
- 97543-3
- Short code
- HCO3 BldCV-sCnc
- Synonyms
- HCO3 BldCV-sCnc
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 22
- Ref high
- 28
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Your body maintains a delicate balance between acids and bases to keep your organs functioning properly. Bicarbonate is one of the main ways your blood helps regulate this balance. Low levels may suggest conditions like metabolic acidosis, while high levels could indicate metabolic alkalosis. This test is often used alongside other blood tests, like blood pH, to diagnose and monitor conditions affecting acid-base balance.
What to Expect Before the Test
No special preparation is usually needed for this test. You may have a small needle inserted into a vein in your arm to draw blood. The process is quick and typically painless. If you’re on blood thinners or have a history of bleeding issues, let your healthcare provider know.
What the Results Mean
Results are usually reported as a concentration value (often in milliequivalents per liter, mEq/L). While reference ranges can vary by lab, very high or very low levels may signal underlying health concerns that need further investigation.
Common Conditions Monitored
Doctors may order this test to diagnose or monitor conditions such as kidney disease, diabetes, heart failure, or gastrointestinal issues that affect acid-base balance. It’s also used in cases of suspected metabolic disorders or after injuries that might disrupt normal blood chemistry.
Reference range
NCBI: HCO3- 22-28 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Bicarbonate Level
Frequently asked questions
What causes bicarbonate levels to be too high or too low?
Can diet affect bicarbonate levels?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy