Bicarbonate concentration in blood (serum/plasma)
This test measures the amount of bicarbonate, a key chemical in your blood that helps balance acidity and alkalinity.
["Bicarbonate helps regulate your body’s pH and supports normal blood pressure and metabolism."]
Key facts at a glance
- LOINC
- 53086-5
- Short code
- HCO3 Fld.NB-sCnc
- Synonyms
- HCO3 Fld.NB-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 22
- Ref high
- 28
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
Bicarbonate is a critical buffer in your blood, helping maintain a stable pH level. Your body produces bicarbonate naturally, and it plays a role in how your kidneys and lungs regulate acid-base balance. Abnormal levels can indicate conditions affecting your metabolism, kidney function, or breathing.
Why Might You Need This Test?
Doctors may order this test if you have symptoms like fatigue, confusion, shortness of breath, or muscle cramps. It’s also used to diagnose or monitor conditions such as metabolic acidosis or alkalosis, kidney disease, or respiratory disorders.
How Is the Test Done?
A small blood sample is drawn from a vein in your arm. The sample is sent to a lab where it’s analyzed to measure bicarbonate levels. No special preparation is needed, but fasting may be required depending on your specific test instructions.
What Are Possible Results?
Results are typically reported in milliequivalents per liter (mEq/L). While reference ranges vary by lab, low levels may suggest metabolic acidosis, while high levels could indicate metabolic alkalosis or other conditions.
Reference range
NCBI: HCO3- 22-28 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Bicarbonate (HCO₃⁻) level
Frequently asked questions
What could cause abnormal bicarbonate levels?
How long will it take to get my results?
Do I need to prepare for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy