: Bicarbonate (Standard) [Substance Concentration] in Whole Blood
: This test measures the concentration of standard bicarbonate in whole blood, a calculated value that reflects the metabolic (non-respiratory) component of your body's acid-base balance.
[": Standard bicarbonate helps show whether an acid-base imbalance is caused by a metabolic problem rather than a breathing problem."]
Key facts at a glance
- LOINC
- 19232-8
- Short code
- HCO3 std BldV-sCnc
- Synonyms
- HCO3 std BldV-sCnc
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 22
- Ref high
- 28
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
: What Is Standard Bicarbonate?
: Bicarbonate is a key buffer that helps keep your blood's pH within a healthy range. "Standard" bicarbonate is a calculated figure that estimates what your bicarbonate would be under standardized breathing conditions, so it focuses on the metabolic side of acid-base balance rather than changes driven by breathing.
: Why the Test Is Done
: This measurement is typically part of a blood gas or electrolyte panel used to evaluate conditions such as metabolic acidosis or metabolic alkalosis, to monitor treatment, or to help interpret acid-base disturbances in acutely ill patients.
: How the Sample Is Collected
: The test is performed on a whole blood sample, usually obtained from an artery or sometimes a vein, and analyzed on a blood gas or chemistry instrument. The standard bicarbonate value is generally calculated from measured pH and carbon dioxide rather than directly measured.
: What the Results Mean
: Results are interpreted together with pH, carbon dioxide, and other electrolytes. A low standard bicarbonate may suggest metabolic acidosis, while a high value may suggest metabolic alkalosis; your care team considers the full picture rather than this value alone.
Reference range
NCBI: HCO3- 22-28 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
: Standard bicarbonate is clinically significant because it isolates the metabolic contribution to acid-base status, helping clinicians distinguish metabolic from respiratory causes of pH changes and guide appropriate treatment and monitoring.
Short name
: Standard Bicarbonate
Frequently asked questions
: Is standard bicarbonate the same as total CO2 or regular bicarbonate?
: Does this test require fasting?
: Can I get results from a home test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy