Bicarbonate concentration in whole blood (electrolyte measurement)
This test measures the amount of bicarbonate, a key chemical in your blood that helps regulate your body’s acid-base balance.
["Bicarbonate helps maintain your blood’s pH level, ensuring proper function of organs and tissues."]
Key facts at a glance
- LOINC
- 12513-8
- Short code
- HCO3 Wat-sCnc
- Synonyms
- HCO3 Wat-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 22
- Ref high
- 28
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
Bicarbonate is a critical buffer in your blood, helping to neutralize acids and maintain a stable pH. Your body tightly controls bicarbonate levels to prevent conditions like acidosis or alkalosis, which can affect how your heart, lungs, and other organs work. This test is often used alongside other blood chemistry tests to assess overall acid-base balance.
Why Might You Need This Test?
Doctors may order this test if you have symptoms like shortness of breath, fatigue, confusion, or muscle weakness—common signs of imbalanced acid-base levels. It’s also used in monitoring conditions like kidney disease, diabetes, or severe dehydration, where bicarbonate levels can change.
How Is the Test Performed?
A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed to measure bicarbonate concentration. No special preparation is needed, but fasting may be required depending on your specific test order.
What Are Common Results?
Results are reported as a concentration value (typically in millimoles per liter, mmol/L). While exact ranges vary by lab, low bicarbonate may indicate acidosis, while high levels could suggest alkalosis. Your doctor will interpret results in the context of your overall health.
Reference range
NCBI: HCO3- 22-28 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Whole Blood Bicarbonate
Frequently asked questions
What causes abnormal bicarbonate levels?
How often should I get this test?
Can I prepare for this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy