Hemoglobin Variants by Autoimmune Screening (Serum)
This test detects certain variations in hemoglobin that may be linked to autoimmune conditions affecting red blood cells. It helps identify unusual hemoglobin forms that could signal underlying immune system activity.
["This test may help diagnose conditions where your body’s immune system attacks red blood cells."]
Key facts at a glance
- LOINC
- 4544-3
- Short code
- Hct VFr Bld Auto
- Synonyms
- Hct VFr Bld Auto
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 36
- Ref high
- 50
- Critical range
- 18 N/A – 60 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- automated-count
- CPT
- 85014
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test analyzes hemoglobin variants in your serum using an automated method to identify specific changes in hemoglobin structure that might be associated with autoimmune reactions. It focuses on detecting abnormal hemoglobin forms that could indicate conditions like autoimmune hemolytic anemia or other red blood cell disorders linked to immune dysfunction.
Why It’s Done
Your healthcare provider may order this test if you have symptoms like fatigue, anemia, or unexplained red blood cell destruction. It’s also used in research or specialized diagnostic settings to study hemoglobin variants in autoimmune diseases.
What to Expect Before the Test
No special preparation is needed. You’ll provide a blood sample drawn from your vein, similar to other routine blood tests. The sample is processed to separate serum for analysis.
What to Expect After the Test
Results are typically reviewed by a laboratory specialist. You’ll receive a report detailing hemoglobin variant profiles, which may include qualitative or semi-quantitative findings. Follow-up with your doctor if they suspect an autoimmune condition.
Reference range
Adult males: 38-50%; Females: 36-44%N/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Autoimmune Hemoglobin Variant Screening
Frequently asked questions
What does a positive or abnormal result mean?
How often should I get this test?
Can lifestyle changes affect this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy