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Hepatitis C Virus Antibody Screen (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the hepatitis C virus, which may indicate past or current infection. Antibodies are your body’s immune response to the virus.

Quick summary

["A positive result suggests exposure to hepatitis C, but further testing is needed to confirm active infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22324-8
Short code
HCV100-3 Ab Ser Ql
Synonyms
HCV100-3 Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have risk factors for hepatitis C, such as exposure to contaminated blood, long-term tattoos/piercings, or a history of intravenous drug use. It’s also used in screening for liver disease or after potential exposure.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample (serum or plasma) via a simple venipuncture. If you’re nervous, let your provider know—they can help minimize discomfort.

What the Test Results Mean

A negative result means you likely don’t have current hepatitis C antibodies. A positive result requires follow-up testing (like HCV RNA) to determine if you have an active infection.

Next Steps After Testing

If positive, your doctor will guide you through next steps, which may include additional tests (e.g., viral load) or referrals to a specialist for treatment options.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Understanding Your Results

Short name

HCV Antibody Screen

Frequently asked questions

Antibodies alone don’t diagnose active hepatitis C. A positive screen must be confirmed with a quantitative HCV RNA test to assess viral load and guide treatment decisions.
This test helps identify potential exposure early, allowing for timely intervention to prevent liver damage or chronic infection.
How long will I need to wait for results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will contact you with the outcome.
Can I drink alcohol before this test?
No, avoid alcohol for 24 hours before testing to ensure accurate results, as it may interfere with antibody detection.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy