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Hepatitis C Virus Antibody Screening Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the Hepatitis C virus (HCV) in your blood. Antibodies are proteins your body makes in response to infection.

Quick summary

["A positive result may indicate past or current Hepatitis C infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51656-7
Short code
HCV Ab s/co Fld
Synonyms
HCV Ab s/co Fld
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test detects the presence of antibodies specific to Hepatitis C virus in your blood. These antibodies develop after your body has been exposed to the virus, which can happen through blood transfusions, sharing needles, or other exposures. The test is designed to identify if you have been infected at any point in your life.

Why It’s Done

Doctors may order this test if you have risk factors for Hepatitis C, such as a history of blood transfusions before 1992, intravenous drug use, or exposure to infected blood. It’s also used as part of routine screening for those at higher risk.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. The process usually takes a few minutes.

What to Expect During the Test

You’ll lie down comfortably while a healthcare provider inserts a needle into your vein. A small amount of blood is collected into a tube. The procedure is quick and typically painless.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

The clinical significance of this test is that it helps identify whether you have been exposed to Hepatitis C virus. Early detection is crucial for managing the infection, as it can lead to chronic liver disease if left untreated. This test is primarily used as a screening tool to guide further diagnostic testing if needed.

Short name

HCV Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies to Hepatitis C virus, suggesting you may have been infected at some point. Further testing, such as a confirmatory HCV RNA test, is needed to determine if the infection is still active.
What does a negative result mean?
A negative result means your blood does not contain detectable antibodies to Hepatitis C virus at this time. However, it’s possible you were infected recently or have been exposed but haven’t developed antibodies yet. Follow-up testing may be recommended if you have risk factors for Hepatitis C.
How often should I get this test?
The frequency of this test depends on your medical history and risk factors. Your healthcare provider will determine the best schedule based on your individual needs, such as whether you have risk factors for Hepatitis C or if you are part of a screening program.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy