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Hepatitis C Virus Antibody, Serum/Plasma (Qualitative)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the hepatitis C virus (HCV) in your blood, which may indicate past or current infection.

Quick summary

["A positive result suggests exposure to hepatitis C; further testing confirms infection status."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104741-4
Short code
HCV Ab s/co SerPl
Synonyms
HCV Ab s/co SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for antibodies produced by your immune system in response to the hepatitis C virus. Antibodies are proteins your body makes to fight infections. If you’ve been exposed to HCV, your immune system may produce these antibodies, even if you’re not currently infected. This test is often used as an initial screening step to check for past or recent exposure.

Why It’s Done

Doctors may recommend this test if you have risk factors for hepatitis C, such as a history of blood transfusions before 1992, needle exposure, or chronic liver issues. It can also be part of routine screening for certain populations at higher risk.

What to Expect

The test involves drawing blood from a vein, usually in your arm. You may feel a slight pinch, but it’s quick and painless. No special preparation is needed, though you should avoid alcohol for 24 hours before the test if advised by your doctor.

Next Steps If Results Are Abnormal

If your screening test is positive, your doctor will likely order additional tests, such as a confirmatory antibody test or viral load test, to determine if you have an active infection. These follow-up tests help guide treatment decisions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HCV Antibody Screen

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test to check for hepatitis C if you have risk factors like intravenous drug use, a history of blood transfusions before 1992, or exposure to contaminated needles. It’s also used in screening for people with chronic liver disease or those with unexplained liver issues.
What does a positive result mean?
A positive result means your body has detected antibodies to the hepatitis C virus, which could indicate past exposure. However, it doesn’t always mean you currently have an active infection. Your doctor will follow up with additional tests to confirm and assess your infection status.
Can I get treated if I test positive?
Yes, if you test positive for hepatitis C antibodies and further testing confirms an active infection, there are effective treatments available to manage and cure the virus. Early treatment improves outcomes and reduces long-term liver damage.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy