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C-reactive protein (CRP) by nephelometry (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein called C-reactive protein, which your body produces in response to inflammation. It helps assess low-level inflammation that may not be obvious from other tests.

Quick summary

["High-sensitivity CRP helps track subtle inflammation, often used alongside other tests for heart disease or autoimmune conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51649-2
Short code
HCV c100p+5-1-1 Ab Ser Ql IB
Synonyms
HCV c100p+5-1-1 Ab Ser Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Your doctor may order this test to monitor chronic inflammation, evaluate risk for heart disease, or check for signs of conditions like rheumatoid arthritis or other autoimmune diseases. It’s sometimes used in research or follow-up for patients with known inflammatory conditions.

What to Expect

A small blood sample is taken from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The test is quick and doesn’t require special preparation beyond standard blood draw guidelines.

How It Works

The lab uses a specialized technique called nephelometry to detect and measure tiny amounts of CRP in your blood. This method is highly sensitive, allowing it to pick up very low levels of inflammation that other tests might miss.

What the Results Mean

Results are reported in milligrams per liter (mg/L). Higher levels may indicate ongoing inflammation, while lower levels suggest reduced inflammation. Your doctor will interpret results in the context of your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

High-sensitivity CRP (hs-CRP)

Frequently asked questions

What does a high CRP level mean?
A high CRP level often signals inflammation in your body, which can be linked to conditions like heart disease, infections, or autoimmune disorders. However, it’s not specific to any single condition—your doctor will consider other factors to guide further testing or treatment.
Why might my CRP level be elevated?
Elevated CRP can occur due to infections, injuries, or chronic health conditions like arthritis. It may also be temporary, such as after surgery or an illness. Your doctor will review your symptoms and medical history to determine the cause.
How often should I get this test?
The frequency depends on your health needs. Your doctor may recommend it annually for risk assessment, during follow-up for chronic conditions, or as part of a specific treatment plan. Never adjust your care based on test results alone—always follow your healthcare provider’s guidance.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy