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Hepatitis C Virus Core Antibody, Qualitative (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the core protein of the Hepatitis C virus in your blood. Antibodies may develop after infection, helping your immune system fight the virus.

Quick summary

["This test helps determine if you’ve been exposed to Hepatitis C virus antibodies, which may indicate past infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
81116-6
Short code
HCV core Ab+Ag Ser Ql
Synonyms
HCV core Ab+Ag Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects specific antibodies produced by your immune system in response to the Hepatitis C virus core protein. These antibodies are a sign that your body has encountered the virus, though they may not always mean you currently have an active infection.

How the Test Works

Your blood sample is analyzed using an immunoassay method to identify the presence of these antibodies. If antibodies are found, it suggests exposure to Hepatitis C, but further testing is needed to confirm active infection.

Why It’s Done

Doctors may order this test as part of screening for Hepatitis C, especially if you’ve had risk factors like unprotected exposure to blood or shared needles, or if you live with someone who has Hepatitis C.

Preparation

No special preparation is needed. You may have a small needle inserted into your arm to draw blood, and you can resume normal activities afterward.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate past or possible exposure to Hepatitis C virus antibodies, but they do not confirm current infection. A positive antibody test should be followed by additional tests, such as HCV RNA testing, to determine if the virus is actively replicating.

Short name

HCV Core Antibody (Qualitative)

Frequently asked questions

What does a positive result mean?
A positive result means your body has produced antibodies to Hepatitis C core protein, suggesting past exposure. This does not confirm an active infection and should be followed by further testing to assess current health status.
Can this test detect an active Hepatitis C infection?
No, this test alone cannot confirm an active Hepatitis C infection. It only shows if antibodies to the virus have been detected, which may indicate past exposure. Active infection is typically diagnosed with additional tests like HCV RNA testing.
How soon after exposure might I get a positive result?
Antibodies may take several weeks to months to develop after exposure. Results may not be accurate immediately after exposure, so doctors may recommend retesting if symptoms or risk factors are present.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy