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Hepatitis C Virus Core Antibody, Qualitative (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the core protein of the hepatitis C virus (HCV), helping determine if your body has ever been exposed to the virus.

Quick summary

["Assists in diagnosing past or potential hepatitis C infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49846-9
Short code
HCV core Ag Bld/Mar Donr Ql
Synonyms
HCV core Ag Bld/Mar Donr Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86803
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects antibodies produced by your immune system in response to the hepatitis C virus core protein. If antibodies are present, it suggests exposure to HCV, though they may not always indicate an active infection. This test is often used as part of a screening or confirmatory process.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have risk factors for hepatitis C, such as exposure to contaminated blood, long-term organ transplants, or certain medical procedures. It may also be used after exposure to assess potential infection status.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm. If you’re nervous, let your provider know—they can offer comfort measures.

What to Expect During the Test

The blood sample is collected in a tube and sent to a lab for analysis. Results are typically reported as positive or negative for HCV core antibodies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HCV Core Antibody (Qualitative)

Frequently asked questions

Positive results indicate past or potential exposure to hepatitis C, but they do not confirm an active infection. A follow-up test (such as HCV RNA testing) may be needed to determine if the virus is currently active and whether treatment is required.
This test is not used to diagnose an active hepatitis C infection but is part of a broader evaluation for exposure history.
What does a positive result mean?
A positive result means your body has detected antibodies to the hepatitis C virus core protein, suggesting past exposure. However, this does not always mean you have an active infection. Further testing is needed to clarify the situation.
Can I get hepatitis C from this test?
No, this test involves only blood collection and does not transmit any infections. Your blood is handled safely and disposed of properly after testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy