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Hepatitis C Virus Genotype and Subtype Detection by Nucleic Acid Amplification Probe

Published: August 9, 2026Updated: August 16, 2026

This test identifies the specific type (genotype) and subtype of the Hepatitis C Virus (HCV) in your blood, helping doctors determine the best treatment plan.

Quick summary

["Your HCV type and subtype help guide personalized treatment options and monitor response to therapy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49607-5
Short code
HCV Gentyp Tiss NAA+probe
Synonyms
HCV Gentyp Tiss NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.8
Ref high
1.2
Critical range
— – 5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
85610
SNOMED
396252006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters for Your Health

Hepatitis C is caused by the HCV virus, which can damage your liver over time. Knowing your HCV genotype and subtype helps healthcare providers choose the most effective antiviral medications and plan for long-term management.

How the Test Works

This test uses a specialized probe to detect and confirm the presence of HCV genetic material in your blood. It involves extracting viral RNA from a serum or plasma sample and amplifying it to identify specific genetic sequences unique to different HCV genotypes (1–6) and subtypes.

Sample Collection and Preparation

A blood sample is drawn from your arm, and the serum or plasma portion is tested. The lab processes the sample to isolate viral RNA, which is then analyzed using a molecular technique to detect HCV genotypes and subtypes.

What to Expect Before the Test

No special preparation is needed for this test. You may have a slight bruise or soreness at the injection site, but this usually resolves quickly. If you’re pregnant, have a weakened immune system, or are on certain medications, inform your doctor before testing.

Reference range

INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A

Specimen: serum

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HCV Genotype/Subtype Test

Frequently asked questions

Your HCV genotype and subtype determine which antiviral medications will be most effective. For example, genotype 1 often responds differently to genotype 3 treatments. This information also helps monitor treatment success and adjust care as needed.
This test is not used to diagnose acute hepatitis C but confirms chronic infection and guides treatment decisions after an initial HCV antibody test.
How long will results take?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will discuss the findings with you during a follow-up visit.
Can I get this test if I’ve never been tested for HCV before?
No, this test is only performed after an initial HCV antibody test confirms infection. It helps classify the virus type for tailored treatment planning.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy