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Anti-Hepatitis C Virus (HCV) Antibody Screening Test (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the Hepatitis C Virus (HCV) in your blood serum. Antibodies are proteins your immune system makes in response to an infection, such as HCV.

Quick summary

["This screening helps identify if you’ve been exposed to Hepatitis C virus, even if you don’t yet have symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16129-9
Short code
HCV IgG Ser Ql
Synonyms
HCV IgG Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test looks for specific antibodies produced by your immune system in response to Hepatitis C. These antibodies indicate past or current infection with the virus, though they may not appear immediately after exposure. This is a screening test, not a diagnostic one for active infection.

Why Might You Need This Test?

Your healthcare provider may recommend this test if you have risk factors for Hepatitis C, such as a history of blood transfusions before 1992, intravenous drug use, or exposure to contaminated needles. It’s also used as part of routine screening for certain populations.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. The process usually takes a few minutes. You can eat and drink as usual before the test.

What Happens During the Test?

A healthcare professional will clean the area on your arm and insert a small needle to collect blood. The blood sample is then sent to a lab for testing. The test itself is quick, but the results may take a few days to come back.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HCV Antibody Screen (Serum)

Frequently asked questions

What does a positive result mean?
A positive result means your body has detected antibodies against Hepatitis C virus. This could mean you’ve been exposed to the virus at some point, but it doesn’t always mean you currently have an active infection. You’ll need additional tests to confirm if you have active Hepatitis C.
Can I have Hepatitis C if my antibody test is negative?
Yes, it’s possible. Antibodies may take weeks or months to develop after exposure. If you have risk factors for Hepatitis C, your doctor may recommend follow-up testing or other diagnostic procedures to check for active infection.
The frequency depends on your risk factors and medical advice. If you have risk factors for Hepatitis C, your healthcare provider may recommend testing every few years or more frequently if you have ongoing risk behaviors or liver concerns.
Inconclusive results may occur if the test is not sensitive enough or if the window period (time between exposure and antibody development) hasn’t passed yet. Your doctor may order additional tests, such as HCV RNA testing, to better understand your status.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy