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Hepatitis C Virus Nucleic Acid Test, Genotype Determination (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects and identifies the specific type (genotype) of the Hepatitis C virus present in your blood. It helps determine the most effective treatment plan.

Quick summary

["Identifying your Hepatitis C genotype guides treatment choices and outcomes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73655-3
Short code
HCV NS5 Mut Det Islt Genotyp
Synonyms
HCV NS5 Mut Det Islt Genotyp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
genotyping
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have been diagnosed with Hepatitis C or if you are at risk of infection. Genotyping helps tailor treatment to your specific virus type, improving response rates and reducing complications.

How the Test Works

A small blood sample is taken to collect a serum or plasma specimen. The virus genetic material (nucleic acids) is extracted and analyzed to determine which of the seven known Hepatitis C genotypes is present. This process uses advanced molecular techniques to detect and classify the virus.

Sample Collection and Preparation

You will typically have a blood draw from a vein in your arm. The blood is processed to separate serum or plasma, which is then sent to a lab for testing. No special preparation is needed, but avoid alcohol consumption for 24 hours before the test if advised by your provider.

Test Results and Follow-Up

Results will show the specific genotype of Hepatitis C you have. This information is critical for your healthcare team to choose the most appropriate treatment, which may include antiviral medications. Follow-up visits will be scheduled to monitor your response to treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HCV Genotyping (Nucleic Acid)

Frequently asked questions

What Does This Test Tell You About My Health?
This test helps determine the exact type of Hepatitis C virus you have. Different genotypes respond variably to treatments, so knowing your genotype ensures your treatment is as effective as possible. It also helps predict the likelihood of a sustained viral response (SVR), meaning the virus is cleared from your body after treatment.
How Does This Test Differ From Other Hepatitis C Tests?
Unlike antibody tests that detect past or current infection, this test directly identifies the Hepatitis C virus genetic material. It confirms active infection and provides critical genotype information to guide treatment decisions.
Can I Skip This Test If I Already Have Hepatitis C?
No, genotype testing is essential even if you already have Hepatitis C. It ensures your treatment is targeted to your specific virus type, improving treatment success rates and reducing the risk of treatment failure or relapse.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy