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C-reactive protein (CRP) with high-sensitivity immunoassay (HS-CRP)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation, often used to check for subtle signs of inflammation or infection.

Quick summary

["Helps detect low-level inflammation that may not be obvious from other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49377-5
Short code
HCV RNA CSF NAA+probe-aCnc
Synonyms
HCV RNA CSF NAA+probe-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86803
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why It’s Done

Your doctor may order this test to monitor conditions like heart disease risk, autoimmune disorders, or inflammation after surgery or injury. It can also help track response to treatments for conditions like arthritis or infections.

What to Expect

A small blood sample is taken from your arm. The sample is sent to a lab where it’s analyzed using a sensitive immunoassay method to detect CRP levels. Results are usually ready within a few days.

What the Results Mean

CRP levels can vary based on health status, age, and other factors. Higher-than-normal levels may signal inflammation, but they don’t always indicate a specific cause. Your doctor will interpret results in the context of your medical history and other tests.

Common Conditions Monitored

This test is often used to assess risk for cardiovascular events, evaluate inflammatory diseases (such as rheumatoid arthritis), or monitor healing after trauma or surgery. It’s also sometimes used in research or screening for early signs of infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

High-Sensitivity CRP

Frequently asked questions

What does a high CRP level mean?
A high CRP level suggests inflammation is present in your body. This could be due to infection, an autoimmune condition, or other factors like injury or surgery. Your doctor will review the results alongside your symptoms and other tests to determine the next steps.
Can CRP levels change over time?
Yes, CRP levels can fluctuate. They may rise after illness, surgery, or physical stress and return to normal as your body heals. Regular monitoring can help track how well treatments are working or if inflammation persists.
Does diet or exercise affect CRP levels?
Yes, lifestyle factors like diet, exercise, and smoking can influence CRP levels. Eating a heart-healthy diet, staying active, and avoiding smoking may help lower inflammation over time. Always discuss lifestyle changes with your doctor before making significant adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy