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Hepatic Cytochrome P450 Reductase Activity (Serum/Plasma Probe)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity of cytochrome P450 reductase, an enzyme involved in liver metabolism that helps convert certain substances into forms the body can process. It may be used to assess liver function or enzyme activity in specific conditions.

Quick summary

["This test helps evaluate liver enzyme function related to drug metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50023-1
Short code
HCV RNA Pnl SerPl NAA+probe
Synonyms
HCV RNA Pnl SerPl NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if they suspect issues with liver metabolism, enzyme function, or if you’re taking medications that rely on cytochrome P450 pathways. It could also be part of a broader evaluation for conditions affecting liver health or enzyme activity.

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to fast for a few hours before the blood draw if your provider specifies it. Avoid alcohol and certain medications for a set period before testing, as they can affect results.

How the Test Works

A small sample of your blood (serum or plasma) is collected and analyzed to measure enzyme activity. The test detects how efficiently your liver’s cytochrome P450 reductase converts a specific substrate into a measurable product.

What the Results Mean

Results are qualitative (present or absent) and indicate whether enzyme activity is within expected ranges or altered. Abnormal results may signal potential liver dysfunction or metabolic pathway disruptions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cytochrome P450 Reductase Activity

Frequently asked questions

What could cause abnormal results?
Abnormal results may be linked to liver disease, genetic enzyme deficiencies, exposure to toxins, or certain medications that interfere with cytochrome P450 reductase function. Always discuss results with your healthcare provider for personalized interpretation.
How often should I get this test?
This test is not routinely recommended for healthy individuals. It may be ordered periodically if you have ongoing liver concerns, metabolic disorders, or are taking medications that require monitoring of enzyme activity.
Can I take any medications before the test?
Avoid medications known to affect cytochrome P450 pathways (e.g., certain antibiotics, antifungals, or antidepressants) and consult your provider about alcohol use. Follow any fasting instructions if provided.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy