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Hepatitis C Virus RNA (Qualitative) – Specimen Probe

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of Hepatitis C Virus RNA in your blood to check for active infection with the Hepatitis C virus.

Quick summary

Determines if Hepatitis C is currently active in your body.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49380-9
Short code
HCV RNA # Spec NAA+probe
Synonyms
HCV RNA # Spec NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This test measures specific markers in your body, such as antibodies or proteins, to show how your immune system has responded to an infection or to vaccination, and it helps your doctor understand your current immune status.

The test uses a molecular probe to identify genetic material (RNA) from the Hepatitis C virus. If the virus is present, the probe will bind to its RNA, confirming an active infection. This is not a test for past infection or antibodies.

Your doctor may order this test to find out whether you have developed protection after an infection or a vaccine, to confirm a recent or past exposure, or to guide decisions about treatment, boosters, or further follow-up care.

Your healthcare provider may order this test if you have risk factors for Hepatitis C (e.g., exposure to contaminated blood, long-term IV drug use, or receiving blood transfusions before 1992), unexplained liver concerns, or if you test positive for Hepatitis C antibodies.

A small blood sample is usually drawn from a vein in your arm by a trained healthcare professional. The collection takes only a few minutes, you may feel a brief pinch, and the sample is then sent to a laboratory for analysis.

A small blood sample is drawn from a vein, usually in your arm. The blood is processed to isolate RNA for testing. This test does not require fasting.

Your results will show whether the measured markers fall within the expected reference range. A healthcare provider will interpret the values together with your symptoms, medical history, and vaccination status to explain what they mean for you.

Positive results indicate active Hepatitis C infection. Negative results mean the virus RNA was not detected at the time of testing, but you may still have past infection or chronic disease. Follow-up testing may be needed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HCV RNA Probe

Frequently asked questions

This test is critical for diagnosing active Hepatitis C, guiding treatment decisions, and monitoring disease progression. Early detection allows for timely intervention to manage liver damage and prevent complications like cirrhosis or liver cancer.
What does it mean if my test result comes back positive, and what steps should I take next after receiving this result from my doctor?
A positive result means the Hepatitis C virus is actively replicating in your body, requiring medical evaluation and potential antiviral treatment to clear the infection.
Can I still have this test done if I have already been vaccinated, and how long should I wait after my vaccine dose before testing?
No, this test specifically looks for the virus itself, not antibodies. Vaccination does not affect this test result.
Your healthcare provider will determine the frequency based on your risk factors, infection status, and treatment plan. Regular follow-ups may be recommended if you have chronic Hepatitis C.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy