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Hepatitis C Virus RNA (Quantitative) – Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Hepatitis C virus genetic material in your plasma to check for active infection.

Quick summary

["Helps diagnose and monitor Hepatitis C virus infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49372-6
Short code
HCV RNA Spec NAA+probe-Log#
Synonyms
HCV RNA Spec NAA+probe-Log#
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of Hepatitis C, such as fatigue, abdominal pain, or unexplained liver issues, or if you’ve been exposed to the virus. It’s also used to confirm infection after initial screening or to track how your treatment is progressing.

What to Expect Before the Test

No special preparation is needed. You’ll typically have a small needle inserted into your arm to draw a blood sample. If you’re on blood thinners, let your provider know beforehand.

What the Test Results Mean

A positive result means you have detectable Hepatitis C virus RNA, confirming active infection. A negative result means no detectable virus was found in the sample at the time of testing. Results are usually reported in viral load units (e.g., IU/mL), but your provider will interpret them in context with your medical history.

How Results Are Used

Your provider will use these results to guide treatment decisions, such as antiviral medications, and to monitor your liver health over time. If you’re treating an infection, follow-up tests may be scheduled to check response to therapy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Hepatitis C virus RNA testing is critical for diagnosing active infection, guiding treatment decisions, and ensuring proper management of liver disease. Early detection and treatment can prevent long-term liver damage, including cirrhosis or liver cancer. This test helps track viral load changes during treatment to assess effectiveness and adjust therapy as needed.

Short name

HCV RNA (Plasma)

Frequently asked questions

What does a positive HCV RNA result mean?
A positive result confirms you have an active Hepatitis C infection, meaning the virus is present in your blood and actively replicating. This is different from a negative result, which means no detectable virus was found at the time of testing. Your provider will work with you to develop a treatment plan based on these results.
How often should I get this test if I have Hepatitis C?
If you’re newly diagnosed, your provider may recommend follow-up tests every few months to monitor your viral load and liver function. During treatment, tests may be done more frequently to check how well the medication is working. Always follow your healthcare provider’s schedule for testing.
Can I drink alcohol before this test?
It’s best to avoid alcohol for 24 hours before the test, as it may affect liver enzymes or test results indirectly. However, your provider will give specific instructions based on your overall health and any medications you’re taking.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy