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Hepatic Cytochrome P450 Reductase Activity (Serum/Plasma Probe)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity of an enzyme involved in liver metabolism, which helps assess how well your liver can process certain medications and toxins.

Quick summary

["This test helps evaluate liver function and drug metabolism support."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49379-1
Short code
HCV RNA Tiss NAA+probe-aCnc
Synonyms
HCV RNA Tiss NAA+probe-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if they suspect liver issues, such as liver disease, or if you’re taking medications that rely on liver enzymes for metabolism. It can also be used to monitor how well your liver is functioning before or after treatment for conditions like hepatitis or cirrhosis.

What to Expect During the Test

A blood sample will be drawn from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The sample is then processed to measure enzyme activity levels.

Common Conditions Monitored

This test is particularly useful for monitoring patients with liver diseases, those undergoing liver transplants, or individuals taking medications that interact with liver enzymes (e.g., certain antidepressants, antibiotics, or cancer treatments).

Sample Preparation and Storage

The blood sample is collected in a special tube and sent to a lab for analysis. The test may require fresh or refrigerated samples, depending on the lab’s protocols. Follow your healthcare provider’s instructions for handling the sample.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Cytochrome P450 Reductase Activity

Frequently asked questions

How does this test differ from a general liver function test?
This test specifically measures the functional activity of cytochrome P450 reductase, a key enzyme in the liver’s metabolic pathway. While general liver function tests (like ALT, AST, or bilirubin) assess overall liver health, this test focuses on enzyme activity that directly influences how medications and toxins are processed.
What does a low or high result mean?
Low enzyme activity may indicate liver damage, reduced metabolic function, or certain genetic conditions. High activity could suggest liver inflammation or stress, but interpretation depends on clinical context and other test results. Always discuss results with your provider.
Can this test be done at home?
No, this test requires a blood sample collected by a healthcare professional in a clinical setting. Home blood tests for enzyme activity are not standard or accurate for this specific measurement.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy