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Hepatic Cytochrome P450 Reductase Activity (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the enzyme activity involved in liver metabolism, which helps assess how efficiently your liver processes certain medications and toxins.

Quick summary

["Evaluates liver enzyme function related to drug metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49608-3
Short code
HCV RNA Tiss NAA+probe-Log IU
Synonyms
HCV RNA Tiss NAA+probe-Log IU
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86803
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

Cytochrome P450 reductase is a critical enzyme in the liver that transfers electrons to other enzymes involved in drug metabolism. This test evaluates its activity in serum, helping identify how well your liver can process substances like medications or toxins.

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you’re taking medications that rely on liver enzymes for metabolism, or if you have liver-related conditions that could affect enzyme function. It may also be used in research or specialized clinical scenarios.

How Is the Sample Collected?

A blood sample is drawn from a vein, typically in your arm. The serum portion (liquid part after clotting) is used for this test.

What Does the Result Mean?

Results are not typically provided in absolute units here, as this is a qualitative or functional assessment rather than a specific concentration. Lower-than-expected activity may suggest liver dysfunction or impaired metabolism, while normal activity indicates healthy enzyme function.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Cytochrome P450 Reductase Activity

Frequently asked questions

What could cause abnormal results?
Abnormal results may indicate liver disease, genetic enzyme deficiencies, or conditions affecting drug metabolism. However, since this is a functional test rather than a direct measurement of a substance, interpretation requires clinical correlation with patient history and symptoms.
How soon will I get results?
Results may take several days to weeks, depending on lab processing and follow-up needs. Your healthcare provider will discuss this with you during your visit.
Is fasting required for this test?
No fasting is required, as this test measures enzyme activity in serum rather than a specific substance concentration.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy