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Homocysteine/Creatinine Ratio, 24-Hour Urine

Published: August 9, 2026Updated: August 16, 2026

Measures homocysteine relative to creatinine in urine collected over 24 hours, accounting for differences in urine concentration.

Quick summary

["This test evaluates how much homocysteine is present in a full day's urine relative to creatinine."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44378-8
Short code
(Hcys)2/Creat 24h Ur
Synonyms
(Hcys)2/Creat 24h Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures homocysteine and creatinine in a 24-hour urine collection. The homocysteine-to-creatinine ratio helps account for variations in urine concentration.

Why might I need this test?

A doctor may order it when evaluating possible abnormalities in homocysteine metabolism, nutritional status, or a suspected inherited condition. It may also be used alongside blood and other urine tests.

How is the test performed?

You collect all urine for a full 24-hour period according to the laboratory's instructions. The laboratory then measures homocysteine and creatinine and calculates their ratio.

How do I prepare for the test?

Follow the collection instructions provided by the laboratory, including the exact start and end times. Keep the container closed and refrigerated if instructed, and note any missed collections or unusual changes in urine output.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Homocysteine/Creatinine Ratio

Frequently asked questions

Why is creatinine included in this test?
Creatinine is used to adjust the homocysteine measurement for urine concentration. This makes results easier to compare across collections.
How long do I need to collect urine?
Urine is typically collected for exactly 24 hours. Follow the laboratory's timing and storage instructions precisely.
What if I miss part of the collection?
Tell the laboratory or your clinician, because a missed collection can make the result less reliable. Do not assume the test can be accurately interpreted without this information.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy