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Homocysteine (Total) and Creatinine, Random Urine

Published: August 9, 2026Updated: August 16, 2026

Measures total homocysteine and creatinine in a random urine sample. Creatinine helps account for differences in urine concentration.

Quick summary

["This test measures urinary homocysteine while using creatinine to help interpret the result."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30051-7
Short code
(Hcys)2/Creat Ur-Rto
Synonyms
(Hcys)2/Creat Ur-Rto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures total homocysteine in urine. Homocysteine is an amino acid involved in metabolism, and creatinine is measured to help account for how concentrated the urine sample is.

Why might I need this test?

A clinician may order this test to assess homocysteine status, investigate possible nutritional or metabolic factors, or monitor treatment. It may be used alongside blood and other urine tests.

How is the test performed?

A random urine sample is collected in a sterile container and analyzed in the laboratory. The laboratory reports homocysteine and creatinine measurements so the clinician can interpret the homocysteine result in the context of urine concentration.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional or laboratory. If a first-morning sample is requested, collect it after your usual overnight period; tell the clinician about supplements, medications, pregnancy, and recent changes in diet.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urinary Homocysteine and Creatinine

Frequently asked questions

Is this the same as a blood homocysteine test?
No. This test uses a urine sample, although it may be ordered along with a blood homocysteine test to provide additional information.
Why is creatinine included?
Urine concentration can vary with fluid intake and other factors. Creatinine provides context that helps the clinician evaluate the homocysteine measurement.
Do I need to collect a 24-hour urine sample?
This test is described as using a random urine sample. If your clinician wants a timed or 24-hour collection, follow their specific instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy