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Homocysteine, Mass Concentration in Urine

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of homocysteine, a type of amino acid, in your urine. It helps assess how well your body is processing certain nutrients and may indicate risks for conditions like kidney disease or genetic metabolic disorders.

Quick summary

["Urine homocysteine testing supports kidney health and metabolic function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2431-5
Short code
(Hcys)2 Ur-mCnc
Synonyms
(Hcys)2 Ur-mCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or risk factors for conditions like chronic kidney disease, genetic metabolic disorders, or certain genetic conditions. It may also be part of a broader evaluation for nutrient deficiencies or metabolic imbalances.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to collect a urine sample in the morning, often in a clean container. Follow your provider’s instructions carefully to ensure accurate results.

What the Test Results Mean

Higher-than-normal levels of homocysteine in urine can signal potential health concerns, such as impaired kidney function or genetic metabolic issues. However, results alone don’t diagnose a condition—they’re part of a larger clinical picture.

Common Conditions Linked to Homocysteine Levels

Elevated homocysteine in urine may be associated with chronic kidney disease, certain genetic disorders (like cystathionine beta-synthase deficiency), or metabolic syndromes. Your provider will interpret results in the context of your medical history and other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Homocysteine

Frequently asked questions

What causes elevated homocysteine levels in urine?
Several factors can influence homocysteine levels, including chronic kidney disease, certain genetic mutations, poor nutrition (especially low vitamin B6, B12, or folate), and metabolic disorders. Lifestyle choices like smoking or alcohol use may also play a role.
How is urine homocysteine tested?
The test involves collecting a urine sample, which is then analyzed using advanced laboratory techniques to measure homocysteine concentration. Results are typically reported as a mass concentration in the urine, not directly in blood.
Can diet affect urine homocysteine levels?
Yes, diet plays a role. Foods high in folate, vitamin B6, and B12 (like leafy greens, nuts, and fortified cereals) may help lower homocysteine levels. Conversely, diets low in these nutrients or high in processed foods may increase them. Always follow your provider’s advice on dietary changes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy