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Homocysteine with Creatinine, Serum/Plasma — Mass Measurement, Turbidimetry

Published: August 9, 2026Updated: August 16, 2026

Measures homocysteine in blood, with creatinine sometimes checked at the same time to help assess kidney function and interpret the result.

Quick summary

["Elevated homocysteine can be associated with vitamin B12 or folate deficiency and reduced kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108392-2
Short code
Hcys/Creat Msmt Ur
Synonyms
Hcys/Creat Msmt Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures homocysteine, an amino acid related to cardiovascular and nerve health. Creatinine may also be measured to help evaluate kidney filtration, because kidney function can affect homocysteine levels.

Why might I need this test?

A clinician may order homocysteine to help investigate unexplained anemia, nerve symptoms, or a concern about vitamin B12 or folate deficiency. It may also be used as part of cardiovascular risk assessment, particularly when kidney function is impaired.

How is the test performed?

A blood sample is collected and analyzed in a laboratory using a laboratory measurement method, which may include turbidimetry. If creatinine is also included, the laboratory can provide information about kidney function at the same time.

How do I prepare for the test?

Fasting is usually not required, but follow any instructions provided by your clinician. Tell the laboratory if you take vitamin B12, folate, or other supplements, because they can affect the result.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Homocysteine and Creatinine

Frequently asked questions

Does a high homocysteine result mean I have a heart disease?
No. High homocysteine can be associated with cardiovascular risk, but it does not diagnose heart disease and must be interpreted with your medical history, examination, and other tests.
What can cause homocysteine to be elevated?
Common possibilities include vitamin B12 or folate deficiency and reduced kidney function. Less commonly, medications, lifestyle factors, or inherited conditions may contribute.
Why is creatinine included with this test?
Creatinine helps assess kidney filtration. This is useful because impaired kidney function can increase homocysteine and should be considered when interpreting the result.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy