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Total Homocysteine and Creatinine, Urine — Screening Test

Published: August 9, 2026Updated: August 16, 2026

A urine test that measures total homocysteine and creatinine. Creatinine helps account for how concentrated the urine sample is.

Quick summary

["This test evaluates urinary homocysteine while using creatinine to help interpret the urine concentration."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26582-7
Short code
Hcys/Creat Ur-sRto
Synonyms
Hcys/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures homocysteine, an amino acid involved in metabolism, in a urine sample. It also measures urinary creatinine, which can help adjust the homocysteine result for differences in urine concentration.

Why might I need this test?

A clinician may order this test when evaluating or monitoring concerns related to homocysteine metabolism, including vitamin status or inherited conditions that can increase homocysteine.

How is the test performed?

A urine sample is collected and analyzed in a laboratory. Depending on the instructions provided, the test may use a single urine specimen or a collection over a specified period.

How do I prepare for the test?

Follow the collection instructions exactly, including whether a timed or 24-hour collection is required. Your clinician will advise whether you should avoid vitamins, supplements, medications, or other substances that could affect the result.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Homocysteine and Creatinine

Frequently asked questions

Do I need to fast before this test?
Fasting is generally not required for a routine urine homocysteine test unless your clinician specifically instructs you to fast. Supplements and medications may need to be reviewed before collection.
Why is creatinine measured with urine homocysteine?
Urine concentration can vary from day to day. Measuring creatinine alongside homocysteine helps provide context for the homocysteine result.
Does an abnormal result mean I have a disease?
No single result usually establishes a diagnosis. Your clinician will consider symptoms, medical history, other laboratory tests, and the collection method when interpreting the result.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy