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HDL2 Cholesterol, Serum/Plasma — Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of HDL2 cholesterol, a subfraction of high-density lipoprotein (HDL), in a serum or plasma blood sample.

Quick summary

["This test measures one component of HDL cholesterol as part of a lipid assessment."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26015-8
Short code
HDL2c SerPl-sCnc
Synonyms
HDL2c SerPl-sCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
40
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83700
SNOMED
113079008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

HDL2 cholesterol measures the amount of cholesterol carried in the HDL2 subfraction of high-density lipoprotein. HDL is a family of particles that transport cholesterol through the bloodstream.

Why might I need this test?

This test may be ordered as part of a cholesterol or cardiovascular risk assessment. It can provide additional information about the types of HDL particles present in the blood.

How is the test performed?

A blood sample is collected, and the serum or plasma is analyzed in a laboratory to determine the concentration of HDL2 cholesterol. The exact laboratory method is not specified by the test code.

How do I prepare for the test?

Follow any fasting or timing instructions provided by your clinician or laboratory. If fasting is not required, you can usually drink water and take medications as directed unless your clinician advises otherwise.

Reference range

Adult males: >40 mg/dL; Females: >50 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HDL2 cholesterol

Frequently asked questions

Is HDL2 cholesterol the same as regular HDL cholesterol?
No. HDL2 is a specific subfraction of HDL, while a standard HDL cholesterol test measures cholesterol across all HDL particles.
Does a high HDL2 result mean I am free from heart disease?
No. A result is only one part of cardiovascular risk assessment and must be considered with other cholesterol measurements, medical history, and lifestyle factors.
Does this test require a fasting blood sample?
It depends on the instructions given with the order. Fasting may be requested when the test is part of a complete lipid panel, so confirm with your clinician or laboratory beforehand.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy