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High-Density Lipoprotein Cholesterol, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures HDL cholesterol in blood. HDL helps carry cholesterol away from arteries, so higher levels are generally considered protective.

Quick summary

["HDL cholesterol is a measure of the blood's cholesterol-carrying capacity and is interpreted along with LDL cholesterol and triglycerides."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57936-7
Short code
HDLc 2a SerPl-mCnc
Synonyms
HDLc 2a SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
40
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83700
SNOMED
113079008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures high-density lipoprotein (HDL) cholesterol. HDL is a type of lipoprotein that carries cholesterol through the blood and helps move it away from artery walls.

Why might I need this test?

HDL cholesterol is often checked as part of a lipid panel to assess cardiovascular risk. It is also monitored in people receiving treatment for high cholesterol or other lipid disorders.

How is the test performed?

A blood sample is collected, and the laboratory measures the amount of cholesterol carried by HDL in the serum or plasma portion of the sample.

How do I prepare for the test?

No special preparation is usually required. Follow the laboratory's instructions, and tell your clinician if you are pregnant, recently ill, or taking medicines that may affect cholesterol levels.

Reference range

Adult males: >40 mg/dL; Females: >50 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HDL cholesterol

Frequently asked questions

Is a high HDL cholesterol result always good?
Higher HDL is generally considered protective, but it does not eliminate cardiovascular risk. Your clinician will interpret the result with the rest of your lipid panel and other risk factors.
What causes low HDL cholesterol?
Low HDL can be influenced by genetics, weight, smoking, diabetes, physical inactivity, and some medicines. Repeat testing and assessment of related risk factors may be appropriate.
Do I need to fast before this test?
Fasting is not always required for routine HDL measurement, but instructions can vary when the test is part of a complete lipid panel. Follow the specific instructions provided by your healthcare professional or laboratory.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy