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High-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol, Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

Measures HDL and LDL cholesterol in serum or plasma to help assess cardiovascular risk and guide cholesterol management.

Quick summary

["These cholesterol measurements help identify cardiovascular risk and inform treatment or lifestyle decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16616-5
Short code
HDLc/LDLc SerPl
Synonyms
HDLc/LDLc SerPl
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol in a blood sample. HDL helps transport cholesterol away from arteries, while LDL can contribute to cholesterol buildup in artery walls.

Why might I need this test?

This test may be ordered as part of a cholesterol or cardiovascular risk assessment, during routine screening, or to monitor treatment for high cholesterol. Results can be considered along with triglycerides, total cholesterol, blood pressure, diabetes status, smoking, and family history.

How is the test performed?

A blood sample is collected and analyzed in a laboratory. LDL cholesterol may be measured directly or calculated from other lipid results, depending on the laboratory and the test ordered.

How do I prepare for the test?

Follow any fasting instructions provided by your clinician or laboratory. If fasting is requested, avoid food and beverages other than water for the specified period; otherwise, a nonfasting sample may be acceptable for routine cholesterol assessment.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HDL and LDL Cholesterol

Frequently asked questions

Is this the same as a complete lipid panel?
Not always. This test specifically includes HDL and LDL cholesterol, while a complete lipid panel also usually includes total cholesterol and triglycerides.
Does a high HDL cholesterol result mean I am free of heart disease risk?
No. A high HDL result does not eliminate other cardiovascular risks, such as high LDL cholesterol, high blood pressure, diabetes, or smoking.
Can medications or health conditions affect these results?
Yes. Cholesterol-lowering medicines, recent illness, thyroid disorders, diabetes, and changes in weight or diet can affect cholesterol measurements. Tell your clinician about medications and relevant health conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy