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High-Density Lipoprotein (HDL) Cholesterol — Lipid Profile

Published: August 9, 2026Updated: August 16, 2026

HDL cholesterol measures the “good” cholesterol in your blood and is usually reported as part of a lipid profile, which also includes total cholesterol, LDL cholesterol, and triglycerides.

Quick summary

["HDL cholesterol helps assess cardiovascular risk as part of an overall lipid profile."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105517-7
Short code
HDLFROMLIPIDPROFILE
Synonyms
—
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
40
Ref high
60
Fasting
true
Population
adult
Sex
all
Age range
18–65 years
CPT
83700
SNOMED
113079008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

High-density lipoprotein (HDL) is a protein-and-fat particle that carries cholesterol in the blood. This test measures the amount of cholesterol in HDL and is usually included in a lipid profile.

Why might I need this test?

HDL cholesterol is used to help assess your risk of heart disease and stroke. Your clinician may order it to evaluate cholesterol levels, monitor changes over time, or guide decisions about heart-healthy habits or treatment.

How is the test performed?

A blood sample is drawn and analyzed in a laboratory. HDL cholesterol is often calculated from the results of other cholesterol measurements, although the laboratory may use a direct method in some cases.

How do I prepare for the test?

Fasting for 9 to 12 hours may be recommended, especially if triglycerides are also being measured or if you have recently eaten a high-fat meal. Follow your clinician’s instructions and tell the laboratory if you have fasted.

Reference range

Adult males: >40 mg/dL; Females: >50 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HDL cholesterol

Frequently asked questions

Is HDL cholesterol the same as “good cholesterol”?
Yes. HDL is often called “good cholesterol” because it helps transport cholesterol away from artery walls. The blood test measures the amount of cholesterol carried in HDL.
Do I need to fast before an HDL cholesterol test?
Fasting may be recommended when the test is part of a complete lipid profile, particularly if triglycerides are elevated or you recently ate a high-fat meal. Your clinician or laboratory can confirm whether fasting is required.
Can lifestyle changes improve HDL cholesterol?
Regular physical activity, a heart-healthy eating pattern, weight management, and not smoking can support cardiovascular health and may affect cholesterol levels. Your clinician can help set an appropriate goal based on your overall risk.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy