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High-Density Lipoprotein (HDL) Cholesterol, Serum/Plasma — Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures HDL cholesterol in blood. HDL helps transport cholesterol away from the arteries and is interpreted as part of a full lipid panel.

Quick summary

["HDL cholesterol is one part of your lipid profile and helps assess cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
17845-9
Short code
HDL SerPl Ql
Synonyms
HDL SerPl Ql
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
40
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83700
SNOMED
113079008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures the amount of high-density lipoprotein cholesterol in your blood. HDL is a type of lipoprotein that carries cholesterol between blood cells and tissues.

Why might I need this test?

HDL cholesterol is usually checked as part of a lipid panel to help assess your risk of heart disease and stroke. It may also be monitored if you have cardiovascular disease, diabetes, or are receiving treatment to improve cholesterol levels.

How is the test performed?

A blood sample is collected, and the laboratory measures the amount of HDL cholesterol using a chemical analysis method. The sample may be taken as serum or plasma, depending on the laboratory's test.

How do I prepare for the test?

Follow your clinician's instructions about fasting. Some lipid panels require fasting, while others do not, and water is generally the best choice if you have been asked to fast.

Reference range

Adult males: >40 mg/dL; Females: >50 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HDL Cholesterol

Frequently asked questions

Is HDL cholesterol the same as “good cholesterol”?
Often, yes. HDL is commonly called “good cholesterol” because it helps move cholesterol away from artery walls, although it should still be interpreted as part of your complete lipid profile.
Does this test require fasting?
It depends on the instructions provided by your clinician or laboratory. Fasting may be required for a complete lipid panel, but some HDL tests can be performed without fasting.
Can HDL cholesterol be changed?
Levels may improve with regular physical activity, a heart-healthy eating pattern, weight management, and appropriate treatment of diabetes or high blood pressure. Your clinician can recommend steps based on your overall cardiovascular risk.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy