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High-Density Lipoprotein Cholesterol, Serum/Plasma — Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

This blood test measures HDL cholesterol, a type of cholesterol that helps transport cholesterol away from the arteries and back to the liver.

Quick summary

["HDL cholesterol is often called “good cholesterol,” and its level is interpreted together with LDL cholesterol, triglycerides, and your overall cardiovascular risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49748-7
Short code
HDL SerPl-sCnc
Synonyms
HDL SerPl-sCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
40
Ref high
60
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83700
SNOMED
113079008
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of high-density lipoprotein (HDL) cholesterol in your blood. HDL carries cholesterol from tissues back to the liver, which helps remove it from the bloodstream.

Why might I need this test?

HDL cholesterol is usually measured as part of a lipid panel to assess cardiovascular risk. Your clinician may also order it to monitor cholesterol-lowering treatment, weight changes, diabetes management, or other conditions that can affect cholesterol levels.

How is the test performed?

A blood sample is collected, usually from a vein in your arm, and the laboratory measures the HDL cholesterol in the serum or plasma portion of the sample.

How do I prepare for the test?

You may be asked to fast for about 9 to 12 hours before the test, although some lipid panels do not require fasting. Follow your clinician’s instructions and tell the laboratory if you are pregnant or taking cholesterol-lowering medicines, because these factors can affect interpretation.

Reference range

Adult males: >40 mg/dL; Females: >50 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HDL cholesterol

Frequently asked questions

Is HDL cholesterol the same as “good cholesterol”?
Yes. HDL is commonly called “good cholesterol” because it helps move cholesterol away from artery walls. However, a higher HDL result does not necessarily mean you are free from cardiovascular risk.
Does a low HDL result mean I have heart disease?
No. A low HDL level is one possible cardiovascular risk factor, but it does not diagnose heart disease. Your clinician will interpret it with your other cholesterol results, medical history, and other risk factors.
Can lifestyle changes improve HDL cholesterol?
Regular aerobic exercise, a balanced diet, maintaining a healthy weight, and not smoking can support cardiovascular health and may improve HDL levels. Your clinician can recommend changes based on your complete lipid profile and health history.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy